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Analysis of T-cell proliferation and cytokine secretion in the individuals exposed to arsenic

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Human experimental toxicology

Source : Human & experimental toxicology, Sage Publications, Volume 27, Number 5, p.381–386 (2008)

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Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2008

Abstract : Over six million people in nine districts of West Bengal, India are exposed to very high levels of arsenic primarily through their drinking water. More than 300,000 people showed arsenic-induced skin lesions in these districts. This is regarded as the greatest arsenic calamity in the world. Chronic arsenicosis causes varied dermatological signs ranging from pigmentation changes, hyperkeratosis to non-melanocytic cancer of skin, and also malignancies in different internal organs. Higher incidences of opportunistic infections are found in the arsenic-exposed individuals, indicating that their immune systems may be impaired somehow. We have thus investigated the effect of arsenic on T-cell proliferation and cytokine secretion in 20 individuals with arsenic-induced skin lesions and compared the results with 18 arsenic-unexposed individuals. A marked dose-dependent suppression of Concanavalin A (Con A) induced T-cell proliferation was observed in the arsenic-exposed individuals compared with the unexposed (P lt; 0.001) individuals. This correlated with a significant decrease in the levels of secreted cytokines by the T cells (TNF-alpha, IFN-gamma, IL2, IL10, IL5, and IL4) in the exposed individuals (P lt; 0.001). Thus it can be inferred that arsenic exposure can cause immunosuppression in humans.

Cite this Research Publication : Dr. Raja Biswas, Ghosh, P., Banerjee, N., Das, J. K., Sau, T., Banerjee, A., Roy, S., Ganguly, S., M. Chatterjee, Mukherjee, A., and , “Analysis of T-cell proliferation and cytokine secretion in the individuals exposed to arsenic”, Human & experimental toxicology, vol. 27, pp. 381–386, 2008.

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