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Antibiotic releasing biodegradable scaffolds for osteomyelitis

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Current drug delivery

Source : Current drug delivery, Bentham Science Publishers, Volume 11, Number 6, p.687–700 (2014)

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Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2014

Abstract : Osteomyelitis is characterized by progressive inflammatory bone degeneration. In the management of chronic osteomyelitis, it is necessary to remove the infected bone tissue followed by implantation of an antibiotic releasing biomaterial that can release antibiotic locally for long periods of time. The main carrier used in clinics for this application is polymethylmethacrylate (PMMA) (Eg. Septopal beads). However, major drawback is the need of an additional surgery to remove the beads after therapy, as PMMA is not biodegradable. This necessitates the requirement of biodegradable carrier systems that can release antibiotics and simultaneously support debrided bone formation. This review summarizes biodegradable carrier systems that have been reported for the localised treatment and prophylaxis of osteomyelitis.

Cite this Research Publication : Dr. Manitha B. Nair and Krishnan, A., “Antibiotic releasing biodegradable scaffolds for osteomyelitis”, Current drug delivery, vol. 11, pp. 687–700, 2014.

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