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Antimicrobial Activity of Chitosan-carbon nanotube Hydrogels

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Materials, MDPI AG

Source : Materials, MDPI AG, Volume 7, Number 5, p.3946-3955 (2014)

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Keywords : Anti-microbial activity, Bacteria, Biological materials, Biomaterials, Biomedical applications, Candida tropicalis, Carbon nanotubes, chitosan, Composite scaffolds, Escherichia coli, Hydrogel scaffolds, Hydrogels, infrared spectroscopy, Medical applications, Optical data storage, Optical microscopy, Scaffolds (biology), scanning electron microscopy, Serial dilutions, Staphylococcus aureus, tissue engineering, Water uptake

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2014

Abstract : In the present study, we have prepared chitosan-carbon nanotube (Chitosan-CNT) hydrogels by the freeze-lyophilization method and examined their antimicrobial activity. Different concentrations of CNT were used in the preparation of Chitosan-CNT hydrogels. These differently concentrated CNT hydrogels were chemically characterized using Fourier Transform-Infrared Spectroscopy, Scanning Electron Microscopy and Optical microscopy. The porosity of the hydrogels were found to be 94%. Dispersion of chitosan was observed in the CNT matrix by normal photography and optical microscopy. The addition of CNT in the composite scaffold significantly reduced the water uptake ability. In order to evaluate antimicrobial activity, the serial dilution method was used towards Staphylococcus aureus, Escherichia coli and Candida tropicalis. The composite Chitosan-CNT hydrogel showed greater antimicrobial activity with increasing CNT concentration, suggesting that Chitosan-CNT hydrogel scaffold will be a promising biomaterial in biomedical applications. © 2014 by the authors.

Cite this Research Publication : J. Venkatesan, Dr. Jayakumar Rangasamy, Mohandas, A., Bhatnagar, I., and Kim, S. - K., “Antimicrobial Activity of Chitosan-carbon nanotube Hydrogels”, Materials, vol. 7, pp. 3946-3955, 2014.

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