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Augmentation of murine natural killer cell and antibody dependent cellular cytotoxicity activities by Phyllanthus emblica, a new immunomodulator

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Journal of Ethnopharmacology

Source : Journal of Ethnopharmacology, Volume 44, Number 1, p.55-60 (1994)

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Keywords : Adjuvants, animal, animal cell, animal experiment, animal model, animal tissue, antibody, antibody dependent cellular cytotoxicity, Antibody-Dependent Cell Cytotoxicity, antineoplastic activity, article, ascites tumor, ascorbic acid, Ayurvedic, cell population, controlled study, Cultured, cyclophosphamide, Emblica officinalis, Experimental, gangliotetraosylceramide, Immunologic, immunomodulating agent, Inbred BALB C, killer cell, Killer Cells, lifespan, lymphoma, Medicinal, Medicine, Mice, mouse, Natural, natural killer cell, Neoplasms, Non-U.S. Gov't, nonhuman, oral drug administration, Phyllanthus, plant extract, Plants, spleen, spleen cell, Support, T-Cell, Tumor Cells, unclassified drug

Campus : Kochi

School : School of Medicine

Department : Biochemistry

Year : 1994

Abstract : When administered orally, Phyllanthus emblica, an excellent source of vitamin C (ascorbate), has been found to enhance natural killer (NK) cell activity and antibody dependent cellular cytotoxicity (ADCC) in syngeneic BALB/c mice, bearing Dalton's lymphoma ascites (DLA) tumor. P. emblica elicited a 2-fold increase in splenic NK cell activity on day 3 post tumor inoculation. Enhanced activity was highly significant on days 3, 5, 7 and 9 after tumor inoculation with respect to the untreated tumor bearing control. A significant enhancement in ADCC was documented on days 3, 7, 9, 11 and 13 in drug treated mice as compared to the control. An increase in life span (ILS) of 35% was recorded in tumor bearing mice treated with P. emblica. This increased survival was completely abrogated when NK cell and killer (K) cell activities were depleted either by cyclophosphamide or anti-asialo-GM, antibody treatment. These results indicate: (a) an absolute requirement for a functional NK cell or K cell population in order that P. emblica can exert its effect on tumor bearing animals, and (b) the antitumor activity of P. emblica is mediated primarily through the ability of the drug to augment natural cell mediated cytotoxicity. © 1994

Cite this Research Publication : Ka Suresh and Vasudevan, D. M., “Augmentation of murine natural killer cell and antibody dependent cellular cytotoxicity activities by Phyllanthus emblica, a new immunomodulator”, Journal of Ethnopharmacology, vol. 44, pp. 55-60, 1994.

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