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Autism spectrum disorders: Integration of the genome, transcriptome and the environment

Publication Type : Journal Article

Publisher : Journal of the Neurological Sciences

Source : Journal of the Neurological Sciences, Elsevier, Volume 364, p.167-176 (2016)

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Campus : Kochi

School : School of Arts and Sciences

Department : Computer Science

Year : 2016

Abstract : Autism spectrum disorders denote a series of lifelong neurodevelopmental conditions characterized by an impaired social communication profile and often repetitive, stereotyped behavior. Recent years have seen the complex genetic architecture of the disease being progressively unraveled with advancements in gene finding technology and next generation sequencing methods. However, a complete elucidation of the molecular mechanisms behind autism is necessary for potential diagnostic and therapeutic applications. A multidisciplinary approach should be adopted where the focus is not only on the 'genetics' of autism but also on the combinational roles of epigenetics, transcriptomics, immune system disruption and environmental factors that could all influence the etiopathogenesis of the disease. ASD is a clinically heterogeneous disorder with great genetic complexity; only through an integrated multidimensional effort can modern autism research progress further. © 2016 Elsevier B.V. All rights reserved.

Cite this Research Publication : N. T. Vijayakumar and Dr. M.V. Judy, “Autism spectrum disorders: Integration of the genome, transcriptome and the environment”, Journal of the Neurological Sciences, vol. 364, pp. 167-176, 2016.

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