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Bacterial bioactive metabolites as therapeutic agents: From production to action

Publication Type : Journal Article

Publisher : Sustainable chemistry and Pharmacy

Source : Sustainable chemistry and Pharmacy 2022, 27, 100650

Url :

Keywords : Secondary metabolites Streptomyces Synthetic biology Microbiome Bioactives

Campus : Kochi

School : School of Biotechnology

Department : biotechnology

Year : 2022

Abstract : Bacterial metabolites are one of the primary sources of drugs that we currently use to treat several diseases. However, bacterial drug discovery and development is a challenging and time-consuming process, and the emergence of new diseases and the development of resistance to currently available drugs demand the discovery of new metabolites with better biological activities. The new advancements in microbial technology, omics, genome and metabolic engineering, synthetic biology and the interdisciplinary approach of these fields overcome the hurdles in drug discovery and heterologous synthesis from bacteria. The gut microbiome performs a vital role in sustaining human health and aids in tackling various diseases. The metabolites produced by the gut microbiome act as an energy source for colon epithelium, maintain pH, help in cell differentiation and induces apoptosis in abnormal cells. The review discusses about the bacterial derived bioactive compounds, advancements and technologies in bacterial synthesis of bioactive sources and genomic and synthetic biology methods for the bioprospecting of bacterial metabolites. Since the gut microbiome relates to colon health, we have also discussed the techniques comprising probiotics, prebiotics, microbiome transplantation, toxins, and bacteriocins capable of preventing and managing colon associated health condition. Future directions in bacterial bioactive metabolite production are also discussed.

Cite this Research Publication : K B Arun, Raveendran Sindhu, Deepthy Alex, Parameswaran Binod, Arivalagan Pughazhendi, Toms C Joseph, Ashok Pandey, Mohammed Kuddus, Santhosh Pillai, Shibitha Emmanuel, Mukesh Kumar Awasthi and Aravind Madhavan. Bacterial bioactive metabolites as therapeutic agents: From production to action. Sustainable chemistry and Pharmacy 2022, 27, 100650. (IF 5.464). (Corresponding author).

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