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Biochemical diagnosis of alcoholism

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Indian Journal of Clinical Biochemistry

Source : Indian Journal of Clinical Biochemistry, Volume 20, Number 1, p.35-42 (2005)

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Keywords : adult, alanine aminotransferase, albumin, alcohol, alcohol consumption, alcohol liver disease, Alcoholism, article, ascorbic acid, aspartate aminotransferase, Biochemistry, body fat, body mass, body weight, controlled study, correlation analysis, differential diagnosis, erythrocyte, female, globulin, glutathione, glutathione metabolism, hemoglobin determination, human, hyperbilirubinemia, hyperuricemia, hypoalbuminemia, laboratory diagnosis, Liver disease, liver injury, major clinical study, male, mean corpuscular volume, oxidative stress, Reliability, statistical significance, thiobarbituric acid reactive substance

Campus : Kochi

School : School of Medicine

Year : 2005

Abstract : Medically diagnosed alcoholics can be differentiated reliably from non-alcoholics using clinically laboratory tests. In the present study, patients with liver diseases either due to alcohol or without alcohol compared with a group of normal healthy persons. Heavy drinkers showed significantly lower body weight and percent body fat, and low BMI compared with other groups. The percentage of hemoglobin and total number of RBC were found to be significantly decreased, whereas mean corpuscular volume (MCV) significantly increased in alcoholic liver disease (ALD). Hyperbilirubinemia, hyperuricemia and hypoalbuminemia correlate with alcohol intake. Albumin / globulin ratio significantly decreased in ALD. In acute liver injury AST/ALT ratio is ≤ 1.0, whereas in alcoholic hepatitis it is always > 1.0. Moderately elevated level of ALP and high GGT values are good discriminator of alcoholic patients. Alcohol-induced liver injury is linked to oxidative stress as observed by decreased level of reduced glutathione and ascorbic acid, and increased level of thiobarbituric acid reactive substances.

Cite this Research Publication : S. K. Das and Dr. Damodaran Vasudevan, “Biochemical diagnosis of alcoholism”, Indian Journal of Clinical Biochemistry, vol. 20, pp. 35-42, 2005.

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