Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Carbohydrate Polymers
Source : Carbohydrate Polymers, Volume 87, Number 1, p.274-283 (2012)
Url : http://www.scopus.com/inward/record.url?eid=2-s2.0-80054769541&partnerID=40&md5=0c7e88454f3c01cd415348ffdd90fa9d
Keywords : adsorption, AFM, Alginate, Alginate scaffolds, alkaline phosphatase, Alkaline phosphatase activity, Bioactive glass, biodegradation, biomineralization, Cell culture, Composite scaffolds, Cytocompatibility, degradation, FTIR, Glass ceramics, Human periodontal ligament, In-vitro, Nanocomposites, Ocean habitats, Osteosarcoma, Periodontal regeneration, Periodontal tissue, Phosphatases, Protein adsorption, Scaffolds (biology), Supporting structure, Tissue, XRD
Campus : Kochi
School : Center for Nanosciences, School of Dentistry
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Periodontics, Nanosciences and Molecular Medicine
Year : 2012
Abstract : Periodontal regeneration is of utmost importance in the field of dentistry which essentially reconstitutes and replaces the lost tooth supporting structures. For this purpose, nano bioactive glass ceramic particle (nBGC) incorporated alginate composite scaffold was fabricated and characterized using SEM, EDAX, AFM, FTIR, XRD and other methods. The swelling ability, in vitro degradation, biomineralization and cytocompatibility of the scaffold were also evaluated. The results indicated reduced swelling and degradation and enhanced biomineralization and protein adsorption. In addition, the human periodontal ligament fibroblast (hPDLF) and osteosarcoma (MG-63) cells were viable, adhered and proliferated well on the alginate/bioglass composite scaffolds in comparison to the control alginate scaffolds. The presence of nBGC enhanced the alkaline phosphatase (ALP) activity of the hPDLF cells cultured on the composite scaffolds. Thus results suggest that these biocompatible composite scaffolds can be useful for periodontal tissue regeneration. © 2011 Elsevier Ltd. All Rights Reserved.
Cite this Research Publication : Sowmya Srinivasan, Jayasree, R., Chennazhi, K. P., Shantikumar V. Nair, and Dr. Jayakumar Rangasamy, “Biocompatible alginate/nano bioactive glass ceramic composite scaffolds for periodontal tissue regeneration”, Carbohydrate Polymers, vol. 87, pp. 274-283, 2012.