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Biocompatible Conducting Chitosan/polypyrrole-alginate Composite Scaffold for Bone Tissue Engineering

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : International Journal of Biological Macromolecules

Source : International Journal of Biological Macromolecules, Volume 62, p.465-471 (2013)

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Keywords : Alginates, alginic acid, article, biocompatibility, Biocompatible Materials, biomineralization, Bone regeneration, Bone tissue engineering, Cell Culture Techniques, Cell Line, cell proliferation, cell viability, chemical structure, chitosan, composite material, Conducting scaffold, controlled study, degradation, ferric chloride, freeze drying, Glucuronic Acid, Hexuronic Acids, Humans, in vitro study, Materials Testing, oxidizing agent, Polymers, polypyrrole, Polypyrrole-alginate-chitosan, porosity, Pyrroles, scanning electrochemical microscopy, Surface properties, tissue engineering, tissue scaffold, Tissue Scaffolds

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2013

Abstract : A polypyrrole based conducting scaffold was developed by incorporating polypyrrole-alginate (PPy-Alg) blend with chitosan using lyophilization technique and employed this composite as a substrate for bone tissue engineering. PPy-Alg blend was developed by oxidative chemical synthesis of polypyrrole using FeCl3 as oxidizing agent and characterized. The physiochemical characterization of the scaffold was done using SEM, FT-IR along with porosity measurement, swelling and in vitro degradation studies. Surface conductivity of the scaffolds was analyzed using Scanning Electrochemical microscopy (SECM). Results from cell viability and cell proliferation with MG-63 cells using Alamar blue assay confirmed the cytocompatible nature of the developed scaffold. In vitro biomineralization ability of the scaffold was assessed and thus the effectiveness of PPy-Alg/chitosan scaffold in the field of tissue engineering was evaluated. © 2013 Elsevier B.V.

Cite this Research Publication : K. M. Sajesh, Dr. Jayakumar Rangasamy, Nair, S. V., and Chennazhi, K. P., “Biocompatible Conducting Chitosan/polypyrrole-alginate Composite Scaffold for Bone Tissue Engineering”, International Journal of Biological Macromolecules, vol. 62, pp. 465-471, 2013.

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