Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : International Journal of Molecular Sciences
Source : International Journal of Molecular Sciences, Volume 12, Number 3, p.1876-1887 (2011)
Url : http://www.scopus.com/inward/record.url?eid=2-s2.0-79953328796&partnerID=40&md5=ae2284254b2d0674c533621288617712
Keywords : Biocompatible Materials, biomaterial, Bone, Bone and Bones, bone defect, bone prosthesis, bone remodeling, calcium ion, Cartilage, cartilage cell, cell adhesion, cell differentiation, cell proliferation, chemistry, chitin, Drug effects, extracellular matrix, human, Humans, metabolism, molecular scaffold, nanocomposite, nanoparticle, nonhuman, physiology, regeneration, Regenerative medicine, review, tissue engineering, Tissue regeneration, tissue scaffold, Tissue Scaffolds, Wound healing
Campus : Kochi
School : Center for Nanosciences, School of Dentistry
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine, Periodontics
Year : 2011
Abstract : Tissue engineering/regeneration is based on the hypothesis that healthy stem/progenitor cells either recruited or delivered to an injured site, can eventually regenerate lost or damaged tissue. Most of the researchers working in tissue engineering and regenerative technology attempt to create tissue replacements by culturing cells onto synthetic porous three-dimensional polymeric scaffolds, which is currently regarded as an ideal approach to enhance functional tissue regeneration by creating and maintaining channels that facilitate progenitor cell migration, proliferation and differentiation. The requirements that must be satisfied by such scaffolds include providing a space with the proper size, shape and porosity for tissue development and permitting cells from the surrounding tissue to migrate into the matrix. Recently, chitin scaffolds have been widely used in tissue engineering due to their non-toxic, biodegradable and biocompatible nature. The advantage of chitin as a tissue engineering biomaterial lies in that it can be easily processed into gel and scaffold forms for a variety of biomedical applications. Moreover, chitin has been shown to enhance some biological activities such as immunological, antibacterial, drug delivery and have been shown to promote better healing at a faster rate and exhibit greater compatibility with humans. This review provides an overview of the current status of tissue engineering/regenerative medicine research using chitin scaffolds for bone, cartilage and wound healing applications. We also outline the key challenges in this field and the most likely directions for future development and we hope that this review will be helpful to the researchers working in the field of tissue engineering and regenerative medicine. © 2011 by the authors; licensee MDPI, Basel, Switzerland.
Cite this Research Publication : Dr. Jayakumar Rangasamy, Chennazhi, K. P., Sowmya Srinivasan, Shantikumar V Nair, Furuike, T., and Tamura, H., “Chitin Scaffolds in Tissue Engineering”, International Journal of Molecular Sciences, vol. 12, pp. 1876-1887, 2011.