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Chitosan-hyaluronan/nano chondroitin sulfate ternary composite sponges for medical use

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Carbohydrate Polymers

Source : Carbohydrate Polymers, Volume 92, Number 2, p.1470-1476 (2013)

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Keywords : Adhesion studies, article, bandage, Bandages, Biocompatible Materials, biodegradation, biomaterial, Blood, blood clotting, Blood Coagulation, cell adhesion, Cell Line, cell proliferation, Cell Survival, chemistry, chitosan, chondroitin sulfate, Chondroitin sulfates, Cytocompatibility, Cytology, drug effect, fibroblast, Fibroblasts, human, Human dermal fibroblasts, Humans, Hyaluronan, hyaluronic acid, Hydrogels, Medical use, metabolism, Nanocomposites, nanomaterial, Nanoparticles, Nanostructures, Platelet activation, porosity, Size ranges, Ternary composites, thrombocyte activation, Water, Wound dressings

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences

Verified : Yes

Year : 2013

Abstract : In this work chitosan-hyaluronan composite sponge incorporated with chondroitin sulfate nanoparticle (nCS) was developed. The fabrication of hydrogel was based on simple ionic cross-linking using EDC, followed by lyophilization to obtain the composite sponge. nCS suspension was characterized using DLS and SEM and showed a size range of 100-150 nm. The composite sponges were characterized using SEM, FT-IR and TG-DTA. Porosity, swelling, biodegradation, blood clotting and platelet activation of the prepared sponges were also evaluated. Nanocomposites showed a porosity of 67% and showed enhanced swelling and blood clotting ability. Cytocompatibility and cell adhesion studies of the sponges were done using human dermal fibroblast (HDF) cells and the nanocomposite sponges showed more than 90% viability. Nanocomposite sponges also showed enhanced proliferation of HDF cells within two days of study. These results indicated that this nanocomposite sponges would be a potential candidate for wound dressing. © 2012 Elsevier Ltd.

Cite this Research Publication : B. S. Anisha, Sankar, D., Mohandas, A., Chennazhi, K. P., Nair, S. V., and Dr. Jayakumar Rangasamy, “Chitosan-hyaluronan/nano chondroitin sulfate ternary composite sponges for medical use”, Carbohydrate Polymers, vol. 92, pp. 1470-1476, 2013.

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