Back close

Circulating immune complexes in CSF of patient with Tuberculous Meningitis

Publication Type : Journal Article

Source : Indian Journal Exp Biol, 1991

Campus : Kochi

School : School of Medicine

Year : 1991

Abstract : A simple dot enzyme immunoassay (Dot-EIA) was carried out to detect antibody toMycobacterium tuberculosis antigen 5 in cerebrospinal fluid (CSF) specimens from 40 patients with a clinical diagnosis of tuberculous meningitis (TBM). The assay gave a positive reaction in all ten patients with culture proven TBM. In 30 culture negative patients with TBM, the assay was positive at a titre of 1:16 in 18 patients. In 40 patients with non-tuberculous neurological diseases (control group) the assay was negative at a titre of 1:16. The Dot-EIA had an overall sensitivity of 70 % and a specificity of 100 % in the diagnosis of TBM. This assay could be used as a rapid screening test to establish the diagnosis of TBM, particularly in patients in whom bacteriological investigations forMycobacterium tuberculosis in CSF specimens are negative.

Cite this Research Publication : Annamma M, Radhakrishnan V.V. Circulating immune complexes in CSF of patient with Tuberculous Meningitis. Indian J Exp Biol 1991;29:973-976.

Admissions Apply Now