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Current trends in lipid based delivery systems and its applications in drug delivery

Publication Type : Journal Article

Publisher : Asian Journal of Pharmaceutical and Clinical Research

Source : Asian Journal of Pharmaceutical and Clinical Research, Volume 5, Number SUPPL. 3, p.4-9 (2012)

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Keywords : aciclovir, acquired immune deficiency syndrome, amprenavir, archaesome, bexarotene, biodegradation, calcitriol, cyclosporin A, drug administration route, drug carrier, drug delivery system, drug efficacy, drug formulation, drug indication, drug safety, drug stability, estradiol, ethosome, fenofibrate, glycyrrhetinic acid phospholipid complex, herpes simplex, human, immunoliposome, indinavir, insulin, lamivudine, lidocaine, lipid based delivery system, liposome, meloxicam, microemulsion, Monitoring, nanoemulsion, nanoparticle, pickering emulsion, propranolol, review, ritonavir, saquinavir, self emulsifying delivery system, solubilization, tamoxifen, tetracaine, toxicity, transfersome, unclassified drug, unindexed drug, valproic acid, valsartan, vesicular drug delivery system, vesosome, zidovudine

Campus : Kochi

School : School of Pharmacy

Department : Pharmacology

Year : 2012

Abstract : Lipid-based delivery systems are an accepted, proven, commercially viable strategy to formulate pharmaceuticals, for topical, oral, pulmonary or parenteral delivery. Lipid based formulations can be tailored to meet a wide range of product requirements dictated by disease indication, route of administration, cost consideration, product stability, toxicity, and efficacy. The proven safety and efficacy of lipid-based carriers make them attractive candidates for the formulation of pharmaceuticals, as well as vaccines, diagnostics and nutraceuticals. These systems allows oral delivery of poorly soluble API when solubilization through modification of molecular scaffold is not an option The efficacy of these biocompatible systems may be improved if their delivery rate, biodegradation, and site-specific targeting can be predicted, monitored, and controlled. However, the number of applications for lipid-based formulations has expanded as the nature type of active drugs under investigation has become more varied. This article mainly focus on lipid formulations namely microemulsions, self emulsifying delivery systems, nanoemulsions, pickering emulsions, liposomes, phytosomes, transfersomes, ethosomes, archaesomes, vesosomes, lipid microparticles and lipid nanoparticles and their prominent applications in pharmaceutical drug delivery.

Cite this Research Publication : S. Saroj, Baby, D. A., and Dr. Sabitha M., “Current trends in lipid based delivery systems and its applications in drug delivery”, Asian Journal of Pharmaceutical and Clinical Research, vol. 5, pp. 4-9, 2012

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