Publication Type : Journal Article
Thematic Areas : Center for Computational Engineering and Networking (CEN)
Publisher : International Journal of Pharmaceutical Science and Health Care
Source : International Journal of Pharmaceutical Science and Health Care, Volume 2, p.59–66 (2012)
Campus : Amritapuri, Coimbatore
School : School of Biotechnology, School of Engineering
Center : Computational Engineering and Networking
Department : Center for Computational Engineering and Networking (CEN), Sciences
Year : 2012
Abstract : HDACs are enzymes found in eukaryotes. It removes the acetyl group from the lysine residue on the N-terminal regions of histone proteins and the process is called histone deacetylation. It results in the increased positive charge on histones. The DNA possesses negatively charged sugar-phosphate backbone; therefore the positively charged histones bind more firmly to the DNA. This makes the DNA unavailable for the transcription factors and eventually leads to the gene silencing. Rather than histone proteins, HDACs ...
Cite this Research Publication : C. P. Anju, Anusooya, N. J., Deeasree, M., Deepak, O. M., and P. K. Krishnan Namboori, “De Novo designing of HDAC inhibitors in cancer therapy”, International Journal of Pharmaceutical Science and Health Care, vol. 2, pp. 59–66, 2012