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Publication Type : Journal Article
Publisher : Volume 67
Source : Volume 67, Issue 10, p.1873 - 1884 (2011)
Keywords : carbohydrate, Click reaction, dendrimer, peptide, Triazole
Campus : Amritapuri
School : School of Arts and Sciences
Department : Chemistry
Year : 2011
Abstract : We designed and synthesized various peptide dendrimers using a 1,3-dipolar cycloaddition (Click) reaction. The dendritic structures reported here include symmetrical, asymmetrical, and cationic dendrimers with triazole, cystine, aromatic, aliphatic, and Lys–Asp dipeptide cores. The high chemoselectivity of the click reaction allowed us to synthesize good yields of high-purity protected and unprotected dendritic structures. Triazole is an excellent peptide bond mimic, which remains hydrolytically stable. Dendrimer 15a and the core unit 21 gelate in a mixture of organic solvents. We also demonstrated the versatility of the design by synthesizing various carbohydrate-based dendrimers.
Cite this Research Publication : V. Haridas, Sharma, Y. K., Sahu, S., Verma, R. P., Sandhya Sadanandan, and Kacheshwar, B. G., “Designer peptide dendrimers using click reaction”, vol. 67, no. 10, pp. 1873 - 1884, 2011.