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Detection of antibodies against herpes simplex virus in patients with oral cancer.

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Indian journal of cancer

Source : Indian journal of cancer, Volume 21, Number 5-6, p.137 (1984)

Campus : Kochi

School : School of Medicine

Department : Biochemistry

Year : 1984

Abstract : Introduction Most common malignant neoplasm in the oral cavity is squamous cell carcinoma. Herpes simplex virus (HSV) may enhance the development of oral carcinoma in individuals who are already at increased risk of the disease because of tobacco consumption and cigarette smoking and so must be considered as a possible etiologic agent in oral cancer and precancer. Aim To assess and compare the correlation of HSV-1 in oral cancer and precancerous lesions/conditions with healthy subjects. Materials and Methods The study comprised of 150 subjects who were divided into three groups as oral cancer, precancer and control group. Their blood samples were collected and were tested for HSV-1 IgG antibody level, using ‘Herpe Select-1’ ELISA kit. Results There was statistically insignificant difference between the HSV-1 IgG level in cancer and precancer but statistically significant difference was found between the HSV-1 IgG level among control group and cancer/precancer. Conclusion The present study clearly indicates that quantitative estimation of IgG antibody against HSV-1 in cancer/precancer patients will give the clue in the etiology of cancer or precancer. However, further studies with a large sample size should be carried out to determine the role of HSV-1 in etiology of oral cancer and precancer.

Cite this Research Publication : T. V. Kumari, Harikumar, T., Prabha, B., Sasidharan, V. K., and Vasudevan, D. M., “Detection of antibodies against herpes simplex virus in patients with oral cancer.”, Indian journal of cancer, vol. 21, p. 137, 1984.

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