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Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Carbohydr Polym
Source : Carbohydr Polym, Volume 162, p.49-55 (2017)
Keywords : chitosan, Drug Carriers, Drug Delivery Systems, Nanoparticles, particle size, Taxoids
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2017
Abstract : Nanoparticles of two chitosan derivatives - N-succinyl-chitosan (SC) and N-glutaryl-chitosan (GC) - were developed as passive transport systems for taxanes (paclitaxel and docetaxel) using an ionic gelation technique with sodium tripolyphosphate. These nanoparticles had an apparent hydrodynamic diameter of 300-350nm, a ζ-potential of 25-31mV, an encapsulation efficiency of 21-26%, and a drug loading efficiency of 6-13%. DLS and SLS analysis shows that the nanoparticles have a unimodal size distribution and spherical form. Drug release kinetics of the taxane-loaded nanoparticles demonstrates that more than 50% of the loaded taxane could be released upon the degradation of the nanoparticles after targeted delivery. The drug-loaded SC and GC nanoparticles exhibit high cytotoxicity towards AGS cancer cell lines and their antitumor activity is consequently enhanced when compared with free taxanes.
Cite this Research Publication : Y. A. Skorik, Golyshev, A. A., Kritchenkov, A. S., Gasilova, E. R., Poshina, D. N., Sivaram, A. J., and Dr. Jayakumar Rangasamy, “Development of Drug Delivery Systems for Taxanes using Ionic Gelation of Carboxyacyl Derivatives of Chitosan.”, Carbohydr Polym, vol. 162, pp. 49-55, 2017.