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Development of Mucoadhesive Thiolated Chitosan Nanoparticles for Biomedical Applications

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Carbohydrate Polymers

Source : Carbohydrate Polymers, Volume 83, Number 1, p.66-73 (2011)

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Keywords : AFM, Biomedical applications, Cancer cells, Carbodiimide hydrochlorides, Cell uptake, Cells, chitin, chitosan, Crosslinking reaction, Cytocompatibility, Drug delivery, Functional polymers, Gene Delivery, Gene transfer, Hydrogels, In-vitro, Mucoadhesive polymers, Nanoparticles, Thermal study, thioglycolic acid, Thiolated chitosan, Tripolyphosphates

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2011

Abstract : The main objective of this work was to develop nanoparticles (NPs) of a mucoadhesive polymer based on chitosan for biomedical applications. Here, we developed thiolated chitosan (TCS) using thioglycolic acid (TGA) and chitosan in the presence of 1-ethyl-3-3(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) as catalyst. The prepared TCS was characterized using FT-IR and the degree of thiol substitution was found out by Ellman's method. The TCS nanoparticles (TCS-NPs) were developed using ionic cross-linking reaction with pentasodium tripolyphosphate (TPP). The prepared TCS-NPs were characterized by DLS, AFM, FT-IR, TG/DTA, etc. In vitro cytocompatibility and cell uptake studies were also carried out. These studies suggest that the prepared NPs show less toxicity towards normal and cancer cells and they are easily taken up by both the normal and cancer cells. So the prepared TCS-NPs could be used for drug and gene delivery applications. © 2010 Elsevier Ltd.

Cite this Research Publication : A. Anitha, Deepa, N., Chennazhi, K. P., Shantikumar V Nair, Tamura, H., and Dr. Jayakumar Rangasamy, “Development of Mucoadhesive Thiolated Chitosan Nanoparticles for Biomedical Applications”, Carbohydrate Polymers, vol. 83, pp. 66-73, 2011.

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