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Development of Novel Chitin/nanosilver Composite Scaffolds for Wound Dressing Applications

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Journal of Materials Science: Materials in Medicine

Source : Journal of Materials Science: Materials in Medicine, Volume 21, Number 2, p.807-813 (2010)

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Keywords : animal cell, Anti-Bacterial Agents, Anti-microbial agent, antibacterial activity, antibiotic resistance, Antibiotic-resistant microorganisms, Antibiotics, article, Bacteria, bactericidal activity, Bandages, biocompatibility, biodegradation, Blood, blood clotting, chitin, Composite scaffolds, controlled study, cytotoxicity, drug screening, drug synthesis, E. coli, Equipment Design, Escherichia coli, fibroblast, infrared spectroscopy, Materials Testing, Medical applications, Medical Devices, Metallic silver, Microorganisms, mouse, nanocomposite, Nanostructures, Natural biopolymers, nonhuman, priority journal, S. aureus, Scaffolds, scanning electron microscopy, Silver, silver nanoparticles, silver nitrate, Silver sulfadiazines, Staphylococcus aureus, tissue engineering, Tissue engineering applications, Tissue Scaffolds, transmission electron microscopy, wound dressing, Wound dressings, Wound healing, Wound healing applications, X ray diffraction

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2010

Abstract : Antibiotic resistance of microorganisms is one of the major problems faced in the field of wound care and management resulting in complications like infection and delayed wound healing. Currently a lot of research is focused on developing newer antimicrobials to treat wounds infected with antibiotic resistant microorganisms. Silver has been used as an antimicrobial agent for a long time in the form of metallic silver and silver sulfadiazine ointments. Recently silver nanoparticles have come up as a potent antimicrobial agent and are finding diverse medical applications ranging from silver based dressings to silver coated medical devices. Chitin is a natural biopolymer with properties like biocompatibility and biodegradability. It is widely used as a scaffold for tissue engineering applications. In this work, we developed and characterized novel chitin/nanosilver composite scaffolds for wound healing applications. The antibacterial, blood clotting and cytotoxicity of the prepared composite scaffolds were also studied. These chitin/nanosilver composite scaffolds were found to be bactericidal against S. aureus and E. coli and good blood clotting ability. These results suggested that these chitin/nanosilver composite scaffolds could be used for wound healing applications.

Cite this Research Publication : K. Madhumathi, Kumar, P. T. Sudheesh, Abhilash, S., Sreeja, V., Tamura, H., Manzoor, K., Nair, S. V., and Dr. Jayakumar Rangasamy, “Development of Novel Chitin/nanosilver Composite Scaffolds for Wound Dressing Applications”, Journal of Materials Science: Materials in Medicine, vol. 21, pp. 807-813, 2010.

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