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Development of phytovesicles containing triterpenoids from Samadera indica

Publication Type : Journal Article

Publisher : Medknow Publications

Source : Pharmacognosy Research, vol. 7, no. 2, pp. 176-183, 2015

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Keywords : animal experiment, animal model, animal tissue, antifungal activity, antifungal agent, article, Candida albicans, chloramphenicol, chloroform, controlled study, cotrimoxazole, Dimethyl sulfoxide, drug delivery system, drug formulation, drug penetration, drug purification, drug release, drug screening, drug solubility, drug stability, erythema, film, gel, hexane, in vitro study, infrared spectroscopy, mass spectrometry, melting point, methanol, micelle, minimum inhibitory concentration, nonhuman, pH, phosphatidylcholine, phytovesicular gel, plant extract, plant leaf, proton nuclear magnetic resonance, Samadera indica, Samadera indica extract, scanning electron microscopy, Simaroubaceae, skin edema, skin irritation, skin penetration, skin permeability, solvent effect, triterpenoid, unclassified drug, viscosity, zeta potential

Campus : Kochi

School : School of Pharmacy

Department : Pharmaceutics

Year : 2015

Abstract : Introduction: Samadera indica belonging to Simaroubaceae family is being used traditionally for many diseases including arthritis, edema, itching, skin diseases, constipation, and general debility. Objective: The effectiveness of any drug delivery system depends upon its ability to deliver the active components at therapeutic level. In this study, a novel phyto vesicular formulation for the enhanced topical delivery of methanol extract of S. indica in order to treat skin infections was developed. Materials and Methods: The methanol extract fraction of leaves of S. indica which showed more antifungal activity was purified to separate an antifungal compound. Phytovesicles were formulated using the more antifungal fraction in order to treat topical and deep seated fungal infections. Pytovesicles were prepared using 1:2 molar ratio of antifungal triterpenoid from S. indica (AFTSI)-phosphatidylcholine by film hydration method. Results and Discussion: Chloroform 100% fraction of methanol extract of S. indica showed more activity against the fungus Candida albicans. Further purification gave a fraction with minimum inhibitory concentration value of 15.6 mg/ml against C. albicans and showed positive test for triterpenoids. The fraction was named as AFTSI. A compound (20 mg) was isolated from this fraction at an R F value. The phytovesicle gel formulated using AFTSI showed enhanced skin permeability and antifungal activity. Conclusion: The study demonstrated that the phytovesicular gel developed using methanol extract of S. indica would be beneficial for treating deep seated fungal infections. © 2015, Medical Knowledge. All rights reserved.

Cite this Research Publication : Dr. Vidya Viswanad, Zachariah, S. Ma, Sathi, Aa, and Aleykutty, N. Ab, “Development of phytovesicles containing triterpenoids from Samadera indica”, Pharmacognosy Research, vol. 7, no. 2, pp. 176-183, 2015

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