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Diagnostic Significance of pH-Responsive Gd3+-Based T1 MR Contrast Agents

Publication Type : Journal Article

Thematic Areas : Advanced Materials and Green Technologies

Publisher : Investigative Magnetic Resonance Imaging

Source : Investigative Magnetic Resonance Imaging, Volume 23, Issue 1, p.17–25 (2019)

Url :

Keywords : MR contrast agent, pH-mapping, T1-W MRI

Campus : Coimbatore

School : School of Engineering

Center : Center for Excellence in Advanced Materials and Green Technologies, Center for Industrial Research and Innovation (ACIRI)

Department : Civil

Year : 2019

Abstract : We discuss recent advances in Gd-based T1-weighted MR contrast agents for the mapping of cellular pH. The pH plays a critical role in various biological processes. During the past two decades, several MR contrast agents of strategic importance for pH-mapping have been developed. Some of these agents shed light on the pH fluctuation in the tumor microenvironment. A pH-responsive self-assembled contrast agent facilitates the visualization of tumor size as small as 3 mm3. Optimization of various parameters is crucial for the development of pH-responsive contrast agents. In due course, the new contrast agents may provide significant insight into pH fluctuations in the human body.

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