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Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Proceedings of the National Academy of Sciences
Source : Proceedings of the National Academy of Sciences, National Acad Sciences, Volume 104, Number 10, p.3865–3870 (2007)
Keywords : sex differentiation sex-determining gene Oryzias latipes sex reverse transgenic
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2007
Abstract : Although the sex-determining gene SRY/Sry has been identified in mammals, homologues and genes that have a similar function have yet to be identified in nonmammalian vertebrates. Recently, DMY (the DM-domain gene on the Y chromosome) was cloned from the sex-determining region on the Y chromosome of the teleost fish medaka (Oryzias latipes). DMY has been shown to be required for the normal development of male individuals. In this study, we show that a 117-kb genomic DNA fragment that carries DMY is able to induce testis differentiation and subsequent male development in XX (genetically female) medaka. In addition, overexpression of DMY cDNA under the control of the CMV promoter also caused XX sex reversal. These results demonstrate that DMY is sufficient for male development in medaka and suggest that the functional difference between the X and Y chromosomes in medaka is a single gene. Our data indicate that DMY is an additional sex-determining gene in vertebrates.
Cite this Research Publication : M. Matsuda, Shinomiya, A., Kinoshita, M., Suzuki, A., Kobayashi, T., Dr. Bindhu Paul, Lau, E. -lieng, Hamaguchi, S., Sakaizumi, M., and Nagahama, Y., “DMY gene induces male development in genetically female (XX) medaka fish”, Proceedings of the National Academy of Sciences, vol. 104, pp. 3865–3870, 2007.