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Doxorubicin-loaded pH-responsive chitin nanogels for drug delivery to cancer cells

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Carbohydrate Polymers

Source : Carbohydrate Polymers, Volume 87, Number 3, p.2352-2356 (2012)

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Keywords : Cancer cells, Cell culture, Cell lines, Cells, Cellular uptake, chitin, cytotoxicity, Diseases, doxorubicin, Drug delivery, FTIR, In-vitro, Liver cancers, MTT assays, Nanogels, Nanostructured materials, PH-responsive, Responsivity, swelling

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2012

Abstract : This work deals with preparation of doxorubicin loaded chitin nanogels and were characterized by SEM, DLS and FTIR for cancer drug delivery. The in vitro cytotoxicity studies of 130-160 nm sized doxorubicin loaded chitin nanogels were studied using MTT assay on L929, PC3, MCF-7, A549 and HEPG2 confirmed that relatively higher toxicity on cancer cells comparing to normal L929 cells. The internalization studies showed a significant uptake of doxorubicin loaded chitin nanogels in all the tested cell lines. All the above results indicated that doxorubicin loaded chitin nanogels can be used for prostate, breast, lung and liver cancer. © 2011 Elsevier Ltd. All rights reserved.

Cite this Research Publication : Dr. Jayakumar Rangasamy, Nair, A., Rejinold, N. S., Maya, S., and Nair, S. V., “Doxorubicin-loaded pH-responsive chitin nanogels for drug delivery to cancer cells”, Carbohydrate Polymers, vol. 87, pp. 2352-2356, 2012.

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