Publication Type : Journal Article
Publisher : Indian Journal of Physiology and Pharmacology
Source : Indian journal of physiology and pharmacology, DEPARTMENT OF PHYSIOLOGY ALL INDIAN INSTITUTE OF, Volume 49, Number 4, p.422 (2005)
Campus : Amritapuri
School : School of Biotechnology
Center : Cell Biology
Year : 2005
Abstract : We studied effect of exogenous ascorbic acid, α-tocopherol,lecithin and L-ornithine-L-aspartate on serum lipids and proteins inexperimental hepatotoxic Wistar rats. Eleven groups (n = 6) of animals were used. Hepatotoxicity was induced by administering ethanol (1.6g/kg/day) for 28 days. Both preventive and curative options were studied.Percentage increase in body weight was significantly lower in ethanol treated rats Ethanol significantly (Plt;0.05) increased cholesterol, triglycerides and LDL, and decreased protein, albumin and A: G ratio in serum. Ascorbic acid, α-tocopherol, lecithin and L-ornithine-L-aspartate exhibited an ability to counteract the alcohol-induced changes in the body weight and biochemical parameters in preventive and therapeutic models in varying degree. Antioxidants showed better effect.
Cite this Research Publication : M. Maneesh and Jayalekshmi H., “Effect of Ascorbic Acid, Alpha-Tocopherol, Lecithin and L-ornithine-L-aspartate on Ethanol Induced Hypoproteinemia and Hyperlipidemia in Rats”, Indian journal of physiology and pharmacology, vol. 49, p. 422, 2005.