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Effect of exogenous L-ornithine L-aspartate on ethanol induced testicular injury in Wistar rats

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Indian Journal of Clinical Biochemistry

Source : Indian Journal of Clinical Biochemistry, Volume 24, Number 1, p.94-97 (2009)

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Keywords : alcohol, animal experiment, animal model, animal tissue, article, ascorbic acid, body weight, catalase, competitive inhibition, controlled study, drug effect, enzyme activity, glutathione, hydroxysteroid dehydrogenase, male, nonhuman, ornithine aspartate, rat, Rattus norvegicus, superoxide dismutase, testis injury, testis weight, thiobarbituric acid reactive substance, treatment duration, weight change, Wistar rat

Campus : Kochi

School : School of Medicine

Department : Biochemistry

Year : 2009

Abstract : To investigate reversibility of ethanol induced testicular injuries on treatment with L-ornithine-L-aspartate, male Wistar rats were treated with ethanol (1.6g/kg b.wt/day) and L-ornithine- L-aspartate (200mg/kg b.wt/ day) for 4 weeks. L-ornithine-L-aspartate effectively prevented the ethanol induced body and testes weight reduction; changes in testicular weight well correlated with body weight. Drug exhibited an ability to counteract ethanol induced oxidative challenge as it effectively reduced testicular TBARS and increased tissue ascorbic acid, GSH and activities of superoxide dismutase, catalase, GSH-Red and Se-GSH-Px. However the drug didn't show promising effect on inhibitory effect of ethanol on testicular D5, 3-beta and 17-beta HSD (hydroxy steroid dehydrogenase). © 2009 Association of Clinical Biochemists of India.

Cite this Research Publication : D. M. Vasudevan, Mailankot, M., Jayalekshmi, H., and Chakrabarti, A., “Effect of exogenous L-ornithine L-aspartate on ethanol induced testicular injury in Wistar rats”, Indian Journal of Clinical Biochemistry, vol. 24, pp. 94-97, 2009.

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