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Evidence for Oxidative Stress in Osteoarthritis

Publication Type : Journal Article

Publisher : Springer

Source : Indian journal of clinical Biochemistry, Springer, Volume 20, Number 1, p.129–130 (2005)

Campus : Amritapuri

School : School of Biotechnology

Center : Cell Biology

Department : Microbiology

Year : 2005

Abstract : Evidence of increased oxidative stress in patients of osteoarthritis in comparison with healthy control subjects was investigated by measuring the thiobarbituric acid reactive substances (TBARS), vitamin C, reduced glutathione (GSH) and the activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) in erythrocytes. It was observed that osteoarthritis patients were more susceptible to oxidative damage than controls as evident from increased TBARS and decreased ascorbic acid, GSH, catalase andnbsp;GPxnbsp;in erythrocytes. Significant increase in SOD activity found in patients might be an adaptive response. With the understanding of the role of antioxidants in arthritis, it is becoming increasingly clear that these agents seem to be beneficial in osteoarthritis.

Cite this Research Publication : M. Maneesh, Jayalekshmi H., Suma, T., Chatterjee, S., Chakrabarti, A., and Singh, T. A., “Evidence for Oxidative Stress in Osteoarthritis”, Indian journal of clinical Biochemistry, vol. 20, pp. 129–130, 2005.

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