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Expression of a novel endothelial marker, C-type lectin 14A, in epithelial ovarian cancer and its prognostic significance.

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Int J Clin Oncol

Source : Int J Clin Oncol, Volume 22, Issue 1, p.107-117 (2017)

Keywords : adult, aged, Aged, 80 and over, Biomarkers, Tumor, Carcinoma, Ovarian Epithelial, Cell Adhesion Molecules, Chemotherapy, Adjuvant, Disease-Free Survival, Endoglin, female, Follow-Up Studies, Humans, immunohistochemistry, Lectins, C-Type, Microvessels, middle aged, Neoadjuvant Therapy, Neoplasm, Residual, Neoplasms, Glandular and Epithelial, Neovascularization, Pathologic, Ovarian Neoplasms, Platelet Endothelial Cell Adhesion Molecule-1, survival rate, Young Adult

Campus : Kochi

School : School of Medicine

Department : Pathology

Year : 2017

Abstract : OBJECTIVE: /bThe purpose of this study was to evaluate microvessel density (MVD) as assessed by C-type lectin 14A (CLEC14A), which is a new marker for endothelial cells, and compare its expression to CD31 and CD105 in epithelial ovarian cancer (EOC).METHODS: /bMVD was evaluated in tumors (n = 50) from patients with EOC who underwent primary surgery and in patients with EOC who received preoperative chemotherapy (n = 49) using immunohistochemistry with antibodies to CLEC14A, CD31 and CD105. The median duration of follow-up was 24.5 months (range 1-101 months). The effect of prognostic factors on event-free survival (EFS) and overall survival (OS) was assessed using the Cox regression model./ppbRESULTS: /bThe amount of residual disease was found to be an independent prognostic factor in multivariate analysis with respect to EFS (P = 0.009) and OS (P  0.001). The mean MVD of CLEC14A (MVD = 6), in tumors from patients who underwent primary surgery, was significantly lower than that of CD31 (MVD = 25, P  0.0001) and CD105 (MVD = 11, P = 0.018). However, there was no significant correlation between MVD as detected by these markers and clinical outcome. There was no expression of CLEC14A in tumors from patients who received preoperative chemotherapy and the MVD of CD31 and CD105 was significantly reduced (P = 0.001 and 0.006, respectively) in this set of patients./ppbCONCLUSION: /bThis study demonstrates MVD as detected by CLEC14A in EOC. Treatment with chemotherapy reduces tumor blood vessels significantly. We suggest that CLEC14A may be a more specific endothelial marker to assess tumor angiogenesis.

Cite this Research Publication : K. S Priya, Kumar, K., Hiran, K. R., Bindhu, M. R., Nagare, R. P., Vijaykumar, D. K., and Ganesan, T. S., “Expression of a novel endothelial marker, C-type lectin 14A, in epithelial ovarian cancer and its prognostic significance.”, Int J Clin Oncol, vol. 22, no. 1, pp. 107-117, 2017.

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