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Fabrication of a Disposable non-enzymatic Electrochemical Creatinine Sensor

Publication Type : Journal Article

Thematic Areas : Biotech

Publisher : Sensors and Actuators B: Chemical

Source : Sensors and Actuators B: Chemical, Volume 243, p.589 - 595 (2017)

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Keywords : Pseudoperoxidase activity

Campus : Amritapuri, Coimbatore

School : School of Biotechnology, School of Engineering

Center : Biosensor Research Lab, Biotechnology

Department : Sciences, biotechnology

Year : 2017

Abstract : Abstract A disposable non-enzymatic sensor for creatinine was developed by electrodepositing copper on screen printed carbon electrodes. The sensor was characterized using electrochemical and microscopic techniques. Electrochemical detection of creatinine was carried out in phosphate buffer solution of pH 7.4. The estimation was based on the formation of soluble copper-creatinine complex. The formation of copper-creatinine complex was established using the pseudoperoxidase activity of copper-creatinine complex. The sensor showed a detection limit of 0.0746 μM with a linear range of 6–378 μΜ. The sensor exhibited a stable response to creatinine and found to be free from interference from molecules like urea, glucose, ascorbic acid and dopamine. Real sample analysis was carried out with blood serum.

Cite this Research Publication : J. Raveendran, Resmi P. E., Dr. Ramachandran T., Dr. Bipin G. Nair, and Dr. Satheesh Babu T. G., “Fabrication of a disposable non-enzymatic electrochemical creatinine sensor”, Sensors and Actuators B: Chemical, vol. 243, pp. 589 - 595, 2017

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