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Fabrication of Chitin-chitosan/nano TiO2-Composite Scaffolds for Tissue Engineering Applications

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : International Journal of Biological Macromolecules

Source : International Journal of Biological Macromolecules, Volume 48, Number 2, p.336-344 (2011)

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Keywords : 3 (4, 5 dimethyl 2 thiazolyl) 2, 5 diphenyltetrazolium bromide, Animals, article, biocompatibility, biomineralization, bone defect, cell adhesion, Cell death, Cell Line, cell viability, chitin, chitosan, controlled study, fibroblast, Fibroblasts, Fourier Transform Infrared, freeze drying, human, human cell, human tissue, Humans, in vitro study, infrared spectroscopy, mesenchymal stem cell, Mice, Minerals, molecular weight, nanocomposite, Nanostructures, osteoblast, scanning electron microscopy, Spectroscopy, tissue engineering, tissue scaffold, Tissue Scaffolds, Titanium, Titanium dioxide, X ray diffraction, X-Ray Diffraction

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2011

Abstract : In this study, we prepared chitin-chitosan/nano TiO2 composite scaffolds using lyophilization technique for bone tissue engineering. The prepared composite scaffold was characterized using SEM, XRD, FTIR and TGA. In addition, swelling, degradation and biomineralization capability of the composite scaffolds were evaluated. The developed composite scaffold showed controlled swelling and degradation when compared to the control scaffold. Cytocompatibility of the scaffold was assessed by MTT assay and cell attachment studies using osteoblast-like cells (MG-63), fibroblast cells (L929) and human mesenchymal stem cells (hMSCs). Results indicated no sign of toxicity and cells were found attached to the pore walls within the scaffolds. These results suggested that the developed composite scaffold possess the prerequisites for tissue engineering scaffolds and it can be used for tissue engineering applications. © 2010 Elsevier B.V.

Cite this Research Publication : Dr. Jayakumar Rangasamy, Ramachandran, R., Divyarani, V. V., Chennazhi, K. P., Tamura, H., and Shantikumar V Nair, “Fabrication of Chitin-chitosan/nano TiO2-Composite Scaffolds for Tissue Engineering Applications”, International Journal of Biological Macromolecules, vol. 48, pp. 336-344, 2011.

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