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Fabrication of Poly (l-lactic acid)/gelatin Composite Tubular Scaffolds for Vascular Tissue Engineering

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : International Journal of Biological Macromolecules

Source : International Journal of Biological Macromolecules, Volume 72, p.1048 - 1055 (2015)

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Keywords : Electrospun nanofibers, Gelatin-PLLA tubular scaffold, Vascular tissue engineering

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2015

Abstract : The in vitro fabrication of fully functional 3D vascular tissue construct represents one of the most fundamental challenges in vascular tissue engineering. Polymer blending is an effective method for developing, desirable bio-composites for tissue engineering. This study employs the blending of desired characteristics of a synthetic polymer, poly (l-lactic acid) (PLLA) and a biopolymer, gelatin for enhancing cell adhesion sites. Aligned and random PLLA/gelatin nanofibers were fabricated using electrospinning technique. Morphological and chemical characterization of the nanofibrous scaffolds was carried out and the size of fibers ranged from 100 to 500nm. The SEM, fluorescent staining and viability assays revealed an increase in viability and proliferation of Human Umbilical Vein Endothelial Cells (HUVECs) and Smooth Muscle Cells (SMCs) proportional to gelatin content. The aligned fiber morphology helps cells to orient and elongate along their long axis. Thus the results were suggestive of the fact that topographically aligned nanofibrous scaffolds control cellular organization and possibly provide a good support for achieving the vital organization and physical properties of blood vessel.

Cite this Research Publication : K. T. Shalumon, Deepthi, S., Anupama, M. S., Shantikumar V Nair, Dr. Jayakumar Rangasamy, and Chennazhi, K. P., “Fabrication of Poly (l-lactic acid)/gelatin Composite Tubular Scaffolds for Vascular Tissue Engineering”, International Journal of Biological Macromolecules, vol. 72, pp. 1048 - 1055, 2015.

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