Publications

Abstract : Stereoselective total synthesis of Ligraminol E has been achieved in 8 steps in 23.9 % overall yield by employing an imidazolidinone based chiral auxiliary. The key steps involved in the synthesis are the asymmetric glycolate alkylation of (R)‐3‐(2‐(benzyloxy)acetyl)‐4‐isopropyl‐1‐((S)‐1‐phenylethyl)imidazo‐lidin‐2‐one with substituted benzyl bromide and the Mitsonobu reaction of a secondary alcohol and phenolic group.