Back close

Formulation and in-vitro evaluation of chrysophanol topical gel

Publication Type : Journal Article

Publisher : Asian Journal of Pharmaceutics

Source : Asian Journal of Pharmaceutics, Volume 5, Number 2, p.120-124 (2011)

Url :

Keywords : animal experiment, article, carbomer, chrysophanic acid, Dimethyl sulfoxide, drug formulation, drug penetration, drug release, drug stability, female, Glycerol, in vitro study, macrogol 400, male, nonhuman, pH, physical chemistry, rabbit, skin irritation, thermodynamics, viscosity

Campus : Kochi

School : School of Medicine

Department : Department of Biostatistics

Year : 2011

Abstract : This study describes the formulation and characterization of topical gel of chrysophanol containing carbopol as gel base. The partition of drug between skin and the hydrogel matrix was considered to play an important role in the permeation process. The effect of three levels of carbopol and three different permeation enhancers on chrysophanol permeability was determined in vitro. Each formulation was characterized in terms of viscosity, pH, extrudability, spreadability, homogenicity, drug content, skin irritation, stability, and drug release studies. The gel consisting of 1% carbopol as gel base and 15% dimethylsulfoxide showed superior physicochemical and permeability properties and it was ranked best. Reports of pharmacokinetic parameters showed that the drug release is controlled by both diffusion and relaxation processes.

Cite this Research Publication : D. Ta Vasudevan, Gopalakrishnan, Sb, Dinesh, K. Ra, Ravikumar, K. Ga, Sundaram, K. Ra, and Unni, A. K. Ka, “Formulation and in-vitro evaluation of chrysophanol topical gel”, Asian Journal of Pharmaceutics, vol. 5, pp. 120-124, 2011.

Admissions Apply Now