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Functionalised Gold Nanoparticles for Selective Induction of in Vitro Apoptosis among Human Cancer Cell Lines

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Journal of Experimental Nanoscience

Source : Journal of Experimental Nanoscience, Volume 8, Number 1, p.32-45 (2013)

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Keywords : apoptosis, article, breast cancer, cancer cell culture, Cell culture, Cell death, cell strain MCF 7, cell viability, chemical analysis, citrate trisodium, citric acid, controlled study, cytotoxicity, DNA determination, DNA fragmentation, flow cytometry, Gold, gold nanoparticle, Gold Nanoparticles, human, Human breast cancer cells, Human cancer cells, human cell, in vitro study, Kosmotropic salts, lung carcinoma, Metal Nanoparticles, Nanoparticles, Nitrogen compounds, Nuclear morphology, Polyethylene imines, polyethyleneimine, Polyethylenes, priority journal, protein protein interaction, Selective induction

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences

Year : 2013

Abstract : The interaction of citrate- and polyethylene imine (PEI)-functionalised gold nanoparticles (GNP) with cancer cell lines with respect to the cellular response was studied. It was found that GNP/citrate nanoparticles were able to induce apoptosis in human carcinoma lung cell lines A549, but GNP/PEI did not show any reduction in the viability of the cells in human breast cancer cell line MCF-7 and A549 cell lines. FACS data confirmed that the number of apoptotic cells increased with increase in the concentration of GNP/citrate nanoparticles. Decline in cellular expansion and changes in the nuclear morphology were noted after the treatment of GNP/citrate nanoparticles on A549 cell lines, which itself is a direct response for stress induction. The induction of cellular apoptosis was further confirmed by DNA fragmentation assay. These data confirm the potential of GNP/citrate nanoparticle to evoke cell-specific death response in the A549 cell lines. © 2013 Taylor Francis.

Cite this Research Publication : J. C. Mohan, Praveen, G., Chennazhi, K. P., Jayakumar, R., and Shantikumar V Nair, “Functionalised Gold Nanoparticles for Selective Induction of in Vitro Apoptosis among Human Cancer Cell Lines”, Journal of Experimental Nanoscience, vol. 8, pp. 32-45, 2013.

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