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Gold-chitin-manganese Dioxide Ternary Composite Nanogels for Radio Frequency Assisted Cancer Therapy

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : RSC Advances

Source : RSC Advances, Volume 4, Number 11, p.5819-5825 (2014)

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Keywords : Ablation, Breast cancer cells, cancer therapy, Cell culture, Cells, Cellular morphology, chitin, Gold, gold nanoparticle, Manganese oxide, Nanorods, Nanostructured materials, Radio frequencies, Radio frequency source, Radio waves, RF radiation, Ternary composites, ultraviolet spectroscopy

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2014

Abstract : Gold nanoparticles (Au-NPs) based chitin-MnO2 ternary composite nanogels (ACM-TNGs) were prepared by the regeneration of chitin along with MnO2 nanorods (5-20 nm) and the incorporation of 10 nm sized Au-NPs to make ACM-TNGs. They were characterized with FT-IR, TG, and UV spectroscopy. The SEM showed spindle shaped 200 nm sized chitin-MnO2 nanogels (chitin-MnO2 NGs), whereas ACM-TNGs had spindle sizes of 220 nm. The ACM-TNGs were compatible up to 1 mg mL-1 and showed uptake into L929, HDF, MG63, T47D and A375 cell lines without affecting the cellular morphology. ACM-TNGs showed conductivity, and heating under a radio frequency (RF) source at 100 W for 2 min. They also showed the ability to kill breast cancer cells under RF radiation at 100 W for 2 min, when compared with the chitin-MnO2 NGs. The RF assisted ablation of breast cancer cells was confirmed by a live/dead assay. These results suggests that ACM-TNGs could be useful for the RF assisted cancer cells ablation with minimal toxicity compared with MnO2 nanorods.

Cite this Research Publication : N. S. Rejinold, Ranjusha, R., Balakrishnan, A., Mohammed, N., and Dr. Jayakumar Rangasamy, “Gold-chitin-manganese Dioxide Ternary Composite Nanogels for Radio Frequency Assisted Cancer Therapy”, RSC Advances, vol. 4, pp. 5819-5825, 2014.

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