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Heterocyclization of 1-alkyl-2-thiobiureas with α-haloketones

Publication Type : Journal Article

Publisher : Elsevier

Source : Tetrahedron Letters, 2001

Url :

Campus : Amritapuri

School : School of Biotechnology

Verified : No

Year : 2001

Abstract : Synthesis of a range of 1, 2, 4-triazolin-5-ones has been carried out by thermally induced cyclization of 1-aryl/alkyl-2-alkyl isothiobiureas 4. The required isothiobiureas were generated in situ by the reaction of alkyl halides with 1-aryl/alkyl-2-thiobiureas 3 in acidic medium at reflux. The reaction proceeds after S-alkylation of the thiobiureas and is demonstrated by the isolation of the alkyl isothiobiurea intermediates and their subsequent acid catalyzed thermal cyclization.

Cite this Research Publication : M. M. Suni, Vipin A. Nair and C. P. Joshua, "Heterocyclization of 1-alkyl-2-thiobiureas with α-haloketones", Tetrahedron Letters 2001, 42, 97-99

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