Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : International Journal of Biological Macromolecules
Source : International Journal of Biological Macromolecules, vol. 126, pp. 717-730, 2018
Url : https://www.sciencedirect.com/science/article/abs/pii/S0141813018358926
Campus : Amritapuri, Kochi
School : Center for Nanosciences, School of Biotechnology
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Biotechnology
Department : biotechnology, Nanosciences and Molecular Medicine
Year : 2018
Abstract : stimuli drug release nanofibrous membranes of polyurethane/dextran were developed for tailoring of antibacterial wound dressings. Incorporation of dextran in polyurethane (PU) showed increment in hydrophilicity, vapour transmission rate, percentage sorption values, and biodegradability. Dextran also acts as reinforcement filler in PU matrix. Dextran induces a high degree of platelet adhesion and hemostasis potential which is essential for promoting the wound healing process. Moreover, 20 wt% dextran loaded membranes (PU/20D) exhibited enhanced cell proliferation, attachment and viability against 3T3 fibroblasts. Curcumin loaded PU/20 dextran membrane exhibited pH-controlled drug release potency and synergistic antibacterial activity against gram-positive bacteria. It is confirmed that, PU/20D membranes could promote, pH-controlled drug release and synergistic antibacterial activity for a promising wound dressing material.
Cite this Research Publication :
P. Sagitha, Reshmi, C. R., Sundaran, S. P., Anupama Binoy, Dr. Nandita Mishra, and Sujith, A., “In-vitro evaluation on drug release kinetics and antibacterial activity of dextran modified polyurethane fibrous membrane.”, International Journal of Biological Macromolecules, vol. 126, pp. 717-730, 2018