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Insilico Analysis of Micro RNA based target Interaction Associated with Pharmacogenomics of Acquired immune Deficiency Syndrome

Publication Type : Journal Article

Publisher : Elsevier

Source : International Journal of Infectious Diseases

Url :

Campus : Coimbatore

Center : Computational Engineering and Networking

Year : 2016

Abstract : Background: Analysis of micro RNA (miRNAs) based regulatory networks in infectious diseases is a challenging task in the era of post genomics and prediction of the miRNAs associated with pharmacogenomics of acquired Immune Deficiency Syndrome (AIDS) is an initiation towards the miRNA based therapy for AIDS. Methods & Materials: Initially we have taken the list of human genes associated with AIDS from PharmG-KB and further we have analyzed the network of human miRNAs which are associated with AIDS related genes from EnrichR. Finally we performed statistical analysis like P value, Z test and combined score of Students T test and ANNOVA to analyze the significance of those predicted miRNAs towards the Human Immune Virus (HIV) related genes. Results: PharmG KB contains 6 genes (ABCB1, CYCSP5, G6PD, GSTM1, NAT2 and NR1I2) which are associated with the Pharmacogenomics of AIDS

Cite this Research Publication : H Anandaram, DA Anand, Insilico analysis of micro RNA based target interaction associated with pharmacogenomics of acquired immune deficiency syndrome - International Journal of Infectious Diseases, 2016

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