Abstract : The benefits of wireless technology are obvious and tremendously growing, but at the same time risks are also surpassing; mainly in unlicensed band. In particular, wireless technologies integrated into medical system requires high degree of reliability and security, that has resulted in several vulnerabilities making them susceptible to different kinds of threats, raising concerns about how protected they are against data security risks and interference issues. The risksinclude unauthorized changes of device settings, obtaining serial number, patient name, diagnosis, deactivating the device functionalities, thus harming the patient. Traditional Electro Magnetic Compatibility (EMC) and Wireless Coexistence are the two risk factors which are to be mainly emphasized in Wireless Personal Medical Devices (WPMD). Introducing a new wireless service into the environment ensue a pile of threats due to its potential source of Electro Magnetic (EM) energy which impacts other devices and systems operating in the same environment.Henceforth, this work aims at providing a method to improve reliability by integrating heterogeneous wireless technologies to avoid data loss, and to improve the EMC standards. Also, we propose a novel security mechanism for WPMD by integrating Fragmentation with xTEA algorithm to enhance security for the data transfer between WPMDs against a possible set of cyber-attacks in public environment.