ProgramsView all programs
From the news
- Chancellor Amma Addresses the Parliament of World’s Religions
- Amrita Students Qualify for the European Mars Rover Challenge
Publication Type : Journal Article
Publisher : Int J Bioinform Res Appl. 2015;11(4):366-73. PubMed PMID: 26561320
Source : Int J Bioinform Res Appl. 2015;11(4):366-73. PubMed PMID: 26561320
Keywords : HNF4A; PPIs; SNAI2; bioinformatics; cancer progression; cancer types; evolutionary conservation; protein-protein interactions; site-specific rates; slug proteins; zinc finger protein.
Campus : Amritapuri
School : School of Biotechnology
Department : biotechnology
Year : 2015
Abstract : Protein-Protein Interactions (PPI) play a crucial role in deciphering function besides identifying candidates. While the experimental analysis is often time consuming involving number of experiments like pulldown assays, they are not necessarily limiting the ability to detect novel protein interactors. In this work, we discuss the role and putative interactors of SNAI2, a slug protein which is involved in the development of cancer progression. The protein interactions have been deciphered by domain pair exclusion method which gives confidence to already precluded interaction pairs. Additionally, conservation patterns of the slug protein have also been analysed by estimating site-specific evolutionary rates at structural level. Based upon the computational analysis, we consider HNF4A could be a putative candidate to study zinc finger protein slug. We believe, this candidate study augmented with structural conservation will definitely provide novel insights into the design and discovery of new interactions for zinc finger class of proteins besides providing possible clues for discovery of various cancer types associated with this class of proteins.
Cite this Research Publication : Suravajhala P, Singh TR. Is HNF4A a candidate to study zinc finger protein slug? Int J Bioinform Res Appl. 2015;11(4):366-73. PubMed PMID: 26561320