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Lithium hydroxide mediated synthesis of 3,4-disubstituted pyrroles

Publication Type : Journal Article

Publisher : Royal Society of Chemistry

Source : RSC Advances, 2013

Url :

Campus : Amritapuri

School : School of Biotechnology

Verified : No

Year : 2013

Abstract : LiOH·H2O in ethanol was found to be an effective reagent for the synthesis of 3,4-disubstituted pyrrole derivatives by the van Leusen method. In situ formation of chalcones from aromatic aldehydes and enolisable ketones, and their subsequent reaction with tosylmethyl isocyanide resulted in the formation and precipitation of pyrrole derivatives from the reaction medium, in good yields. The solvation effect of the polar medium facilitates the reaction.

Cite this Research Publication : Ratnesh Sharma, Kapil Kumar, Mangilal Chouhan, Vikas Grover and Vipin A. Nair "Lithium hydroxide mediated synthesis of 3,4-disubstituted pyrroles", RSC Advances, 2013, 3, 14521-14527

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