Publication Type : Journal Article
Publisher : Elsevier
Source : Tetrahedron Letters, 2010
Campus : Amritapuri
School : School of Biotechnology
Verified : No
Year : 2010
Abstract : A novel methodology for the synthesis of N-substituted-3-aryl-2-thioxotetrahydropyrimidin-4(1H)-one derivatives had been developed by the condensation of aryl isothiocyanates with β-amino esters using lithium perchlorate as a catalyst and triethylamine as a base. This strategy not only overcomes the disadvantages of the reported methods but also provides high yield of the product in short span of time by an easily workable procedure.
Cite this Research Publication : Varun Kumar and Vipin A. Nair, "Lithium perchlorate-induced electrophilic activation: one-pot synthesis of 3-aryl-2-thioxotetra hydropyrimidin-4-one derivatives from aryl isothiocyanates", Tetrahedron Letters 2010, 51, 966-969.