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Luteolin-Fabricated ZnO Nanostructures Showed PLK-1 Mediated Anti-Breast Cancer Activity.

Publication Type : Journal Article

Publisher : Biomolecules

Source : Biomolecules, Volume 11, Issue 3, p.1-21. (2021)

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Campus : Mysuru

School : School of Arts and Sciences

Department : Sciences

Year : 2021

Abstract : The present work describes a facile and convenient procedure for synthesizing zinc oxide nanoparticles using luteolin isolated from plant (L-ZnONPs) at room temperature. The formation of as-grown L-ZnONPs was confirmed by X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM), and selected area electron diffraction (SAED). The Wurtzite structure of ZnO was observed by its hexagonal phases in diffraction patterns. The SEM images revealed the different sizes and morphologies of L-ZnONPs, with diameters between 12 and 25 nm. The HR-TEM result showed that the inter-planar distance between two lattice fringes was 0.262 nm, which coincides with the d-spacing of (002) and (101) lattice planes of the as-obtained material. The anticancer activity of L-ZnONPs against the breast cancer cell line MCF-7 was greater as compared to that of luteolin or ZnO alone. The mechanistic evaluation of such an activity carried out using in silico methods suggested that the anti-breast cancer activity of L-ZnONPs was mediated by polo-like kinase 1 (PLK1) proteins.

Cite this Research Publication : Shiva Prasad Kollur, Prasad, S. K., Pradeep, S., Veerapur, R., Patil, S. S., Amachawadi, R. G., S, R. Prasad, Lamraoui, G., Al-Kheraif, A. A., Elgorban, A. M., Syed, A., and Shivamallu, C., “Luteolin-Fabricated ZnO Nanostructures Showed PLK-1 Mediated Anti-Breast Cancer Activity.”, Biomolecules, vol. 11, no. 3, pp. 1-21. , 2021.

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