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Lysophosphatidic acid (LPA) receptor modulators: Structural features and recent development.

Publication Type : Journal Article

Publisher : ELSEVIER

Source : Eur J Med Chem, ELSEVIER, Volume 222, p.113574 (2021)

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Campus : Kochi

School : School of Pharmacy

Department : Pharmaceutical Chemistry & Analysis

Year : 2021

Abstract : Lysophosphatidic acid (LPA) activates six LPA receptors (LPAR) and regulates various cellular activities such as cell proliferation, cytoprotection, and wound healing. Many studies elucidated the pathological outcomes of LPA are due to the alteration in signaling pathways, which include migration and invasion of cancer cells, fibrosis, atherosclerosis, and inflammation. Current pathophysiological research on LPA and its receptors provides a means that LPA receptors are new therapeutic targets for disorders associated with LPA. Various chemical modulators are developed and are under investigation to treat a wide range of pathological complications. This review summarizes the physiological and pathological roles of LPA signaling, development of various LPA modulators, their structural features, patents, and their clinical outcomes.

Cite this Research Publication : B. Meduri, Pujar, G. Veeranna, T Kumar, D. Ananda, Akshatha, H. S., Sethu, A. Kumar, Singh, M., Kanagarla, A., and Bijo Mathew, “Lysophosphatidic acid (LPA) receptor modulators: Structural features and recent development.”, Eur J Med Chem, vol. 222, p. 113574, 2021.

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