Publication Type : Journal Article
Publisher : Researchgate
Source : International Journal of Pharmacy and Pharmaceutical Sciences, 2014
Campus : Bengaluru
School : School of Artificial Intelligence
Verified : No
Year : 2014
Abstract : Aromatase is a key enzyme that plays a crucial role in the synthesis of estrogen and has a major effect in pathogenesis of estrogen-dependent disease, including breast cancer, endometrial cancer, and endometriosis. The abnormal over expression of aromatase can be inhibited by aromatase inhibitors. The objective of the present study is to evaluate the binding interaction of flavonoid compounds with cytochrome P450 enzyme aromatase, which is involved in the metabolism of estrogens and considered as a powerful target for treatment of estrogen-dependent breast cancers.
Cite this Research Publication : Indu AG, Munusami P, Vasavi CS, Molecular docking studies on flavonoid compounds: an insight into aromatase inhibitors. International Journal of Pharmacy and Pharmaceutical Sciences. 2014; 6: 141–148, Innovare Academic Sciences, Impact Factor: 0.51