Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : International journal of biological macromolecules
Source : International journal of biological macromolecules, Elsevier, Volume 67, p.279–288 (2014)
Url : http://www.sciencedirect.com/science/article/pii/S0141813014002098
Keywords : Chitin; PLGA; Composite nanogels; Microbial and cellular imaging; Hyperthermia
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2014
Abstract : Cyto-compatible, 80 nm sized chitin/PLGA composite nanogels (chit/PLGA-comp NGs) were prepared by regeneration method and characterized. The multifaceted chit/PLGA-comp NGs were surface modified with Au, Fe3O4, CdTe/ZnTe-QDs and umbelliferone, respectively. 185 nm sized Au-chit/PLGA-comp NGs, 170 nm sized QD-chit/PLGA-comp-NGs and 160 nm sized Fe3O4-chit/PLGA-comp-NGs showed RF heating. The QD-chit/PLGA-comp-NGs and 180 nm sized umb-chit/PLGA-comp-NGs were well uptaken by Escherichia coli, Staphylococcus aureus and Candida albicans. The chit/PLGA-comp NGs could be useful for microbial monitoring and RF application for cancer therapy. The preliminary data showed that multifaceted chit/PLGA-comp-NGs could be useful for hyperthermia for cancer treatment and microbial labelling and imaging.
Cite this Research Publication : S. N Rejinold, Dr. Raja Biswas, Chellan, G., and Dr. Jayakumar Rangasamy, “Multifaceted Chitin/poly (lactic-co-glycolic) Acid Composite Nanogels”, International journal of biological macromolecules, vol. 67, pp. 279–288, 2014.