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Murexide-Derived In Vitro Electrochemical Sensor for the Simultaneous Determination of Neurochemicals

Publication Type : Journal Article

Publisher : Analytical and bioanalytical chemistry

Source : Analytical and bioanalytical chemistry, 2021

Keywords : Dopamine; Electrochemical; Murexide; Serotonin; Simultaneous; Tryptamine.

Campus : Amritapuri

School : School of Arts and Sciences

Center : Research & Projects

Department : Chemistry

Verified : Yes

Year : 2021

Abstract : This work highlights the protocol employed for the simultaneous electroanalysis of tryptamine, serotonin and dopamine using a conducting poly-murexide-based electrode. To date, this is the first-of-its-kind report of simultaneous electrochemical determination of these three targets. Features of the developed electrode were identified by employing FE-SEM analysis. Under optimized conditions, the analytes underwent an irreversible electro-oxidation at the modified electrode surface, with a linear range of 0.5-40 μΜ, 0.4-40.4 μΜ and 0.5-40 μΜ for dopamine, serotonin and tryptamine, respectively. The electrolytic medium employed for the sensing was a phosphate-buffered solution with pH 7. The specificity of the developed electrode was also satisfactory in the presence of other biomolecules including L-phenylalanine, L-serine, glucose and ascorbic acid. Thus, the developed murexide-derived conducting-polymer-based electrode was used for the simultaneous sensing of the neurochemicals dopamine, serotonin and tryptamine. Electroanalysis was also demonstrated for these targets in human serum.

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