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N-acetyl cysteine in liver resection.

Publication Type : Journal Article

Publisher : J Surg Oncol

Source : J Surg Oncol, Volume 114, Issue 6, p.773 (2016)

Keywords : acetylcysteine, Delirium, Drug Administration Schedule, Free Radical Scavengers, Hepatectomy, Humans, India, liver transplantation, Living Donors, Perioperative Care, Postoperative Complications

Campus : Kochi

Year : 2016

Abstract : Background and objectives: Liver failure following hepatic resection is a multifactorial complication. In experimental studies, infusion of N-acetylcysteine (NAC) can minimize hepatic parenchymal injury. Methods: Patients undergoing liver resection were randomized to postoperative care with or without NAC. No blinding was performed. Overall complication rate was the primary outcome; liver failure, length of stay, and mortality were secondary outcomes. Due to safety concerns, a premature multivariate analysis was performed and included within the model randomization to NAC, preoperative ASA, extent of resection, and intraoperative vascular occlusion as factors.

Cite this Research Publication : Z. Umer Mohamed, Krishnakumar, L., and Sudhindran, S., “N-acetyl cysteine in liver resection.”, J Surg Oncol, vol. 114, no. 6, p. 773, 2016.

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