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Paclitaxel loaded fibrinogen coated CDTE/ZNTE core shell nanoparticles for targeted imaging and drug delivery to breast cancer cells

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Journal of Biomedical Nanotechnology

Source : Journal of Biomedical Nanotechnology, American Scientific Publishers, Volume 9, Number 10, p.1657-1671 (2013)

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Keywords : animal cell, animal experiment, Aqueous-phase synthesis, article, breast cancer, Cadmium telluride, cadnium telluride, calcium chloride, cancer cell, cancer localization, Cells, Cellular imaging, controlled study, Cytology, Diseases, Drug delivery, drug delivery system, drug release, female, fibrinogen, fluorescence microscopy, Glycoproteins, HeLa cell line, human, human cell, hydrogen bond, in vitro study, Integrins, MCF 7 cell line, Medical imaging, mouse, MTT assay, nonhuman, paclitaxel, particle size, QDs, quantum dot, Semiconductor quantum dots, synthesis, tellurium, unclassified drug, very late activation antigen 5, zeta potential, zinc telluride

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences

Verified : Yes

Year : 2013

Abstract : The study aims at the targeted imaging using CdTe/ZnTe core shell QDs and delivery of paclitaxel (PTX) loaded fibrinogen coated yellow-QDs (PTX-fib-yellow-QDs) towards breast cancer cells via the α5 β1 -integrins. We developed fibrinogen coated different sized CdTe/ZnTe core shell quantum dots of 2-10 nm size, which have been prepared by one-pot aqueous-phase approach. The fib-coated-QDs (fib-coated-QDs) and PTX-fib-yellow-QDs were prepared by twostep coacervation technique using CaCl2 as cross-linker. Particle size of fib-coated-QDs was in between 60-220 nm while PTX-fib-yellow-QDs showed 180 ± 40 nm. The MTT assay confirmed cytocompatibility of fib-coated-QDs on L929 and MCF-7 than bare QDs, whereas significant toxicity toward MCF-7 by PTX-fib-yellow-QDs was observed. The hemocompatible fib-coated-QDs showed enhanced localization and retention toward α5 β1 -integrins +ve MCF-7 compared to α5 β1 -integrins -ve L929 cells. The specific binding of fib-coated-yellow-QDs was further confirmed with α5 β1 -integrins +ve HeLa and α5 β1 -integrins -ve HT29 cells. Cellular uptake studies revealed localization of PTX-fib-coated-yellow-QDs inside MCF-7 cells compared to the normal L929 cells. These results indicated that fib-coated-QDs could be used for targeted imaging and as a suitable nanocarrier aiming breast cancer cells. Copyright © 2013 American Scientific Publishers All rights reserved.

Cite this Research Publication : N. S. Rejinold, Baby, T., Nair, S. V., and Dr. Jayakumar Rangasamy, “Paclitaxel loaded fibrinogen coated CDTE/ZNTE core shell nanoparticles for targeted imaging and drug delivery to breast cancer cells”, Journal of Biomedical Nanotechnology, vol. 9, pp. 1657-1671, 2013.

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