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Peptide Nucleic Acid monomers and a preparation method thereof

Publication Type : Patents

Publisher : Indian Patent application, Filed, Number 201741020193 (2017)

Source : U.S. Patent 2017410201932017.

Campus : Coimbatore

School : School of Engineering

Center : Analytical Chemistry

Department : Chemistry

Year : 2017

Abstract : The disclosure in various embodiments is related to a peptide nucleic acid monomer (VI) and an improved process for preparation of PNA (VI) using nosyl-group containing starting material. The process includes reacting amino acid with a nosyl group. The nosyl protected amino acid is alkylated with 2-(Boc-amino)ethyl bromide to obtain an intermediate. The nosyl group of the obtained intermediate is removed to form a PNA backbone. The PNA backbone upon addition of a modified nucleobase results in the formation of a PNA monomer (VI). The obtained PNA monomer exhibits either chiral or achiral geometric properties.

Cite this Research Publication : P. Ramani, “Peptide Nucleic Acid monomers and a preparation method thereof”, U.S. Patent 2017410201932017.

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