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Publication Type : Patents
Publisher : Indian Patent application, Filed, Number 201741020193 (2017)
Source : U.S. Patent 2017410201932017.
Campus : Coimbatore
School : School of Engineering
Center : Analytical Chemistry
Department : Chemistry
Year : 2017
Abstract : The disclosure in various embodiments is related to a peptide nucleic acid monomer (VI) and an improved process for preparation of PNA (VI) using nosyl-group containing starting material. The process includes reacting amino acid with a nosyl group. The nosyl protected amino acid is alkylated with 2-(Boc-amino)ethyl bromide to obtain an intermediate. The nosyl group of the obtained intermediate is removed to form a PNA backbone. The PNA backbone upon addition of a modified nucleobase results in the formation of a PNA monomer (VI). The obtained PNA monomer exhibits either chiral or achiral geometric properties.
Cite this Research Publication : P. Ramani, “Peptide Nucleic Acid monomers and a preparation method thereof”, U.S. Patent 2017410201932017.