Publication Type : Journal Article
Publisher : Indian Journal of Nuclear Medicine
Source : Indian Journal of Nuclear Medicine, Volume 26, Number 2, p.99-101 (2011)
Keywords : adolescent, anti n methyl dextro aspartate receptor encephalitis, article, artificial ventilation, aspiration pneumonia, behavior change, blood pressure variability, bone marrow biopsy, bradycardia, brain metabolism, bruxism, case report, cerebrospinal fluid analysis, computer assisted emission tomography, facial expression, female, fluorodeoxyglucose f 18, haloperidol, human, hyperventilation, Intubation, leg movement, mastication, mental deterioration, oculogyric crisis, paraneoplastic neuropathy, promethazine, protein restriction, seizure, steroid, tachycardia, tic, whole body CT, whole body PET
Campus : Kochi
School : School of Medicine
Department : Department of Nuclear Medicine and Molecular Imaging
Year : 2011
Abstract : Anti N-methyl-d-aspartate receptor encephalitis (ANMDARE), also known as limbic encephalitis (LE), is a treatable rare disorder characterized by personality changes, irritability, depression, seizures, memory loss and sometimes dementia. It is classified under paraneoplastic syndrome (PNS) and produces antibodies against NR1 and NR2 subunits of glutamate aspartate receptor. It is thought to be closely related with malignancies like small cell lung cancer, ovarian teratoma and Hodgkins lymphoma, apart from testis, breast and rarely gastric malignancies. Non-paraneoplastic encephalitis cases are the ones with no detectable malignancy and may be triggered by severe infection. As nuclear medicine physicians, we must be aware of the diverse presentation of ANMDARE or LE and should include a whole body positron emission tomography / computed tomography (PET/CT) and not just brain PETCT during imaging. We describe the first case of PET/CT in an idiopathic ANMDARE Indian adolescent girl.
Cite this Research Publication : Sa Padma, Sundaram, P. Sa, and Marmattom, B. Vb, “PET/CT in the evaluation of anti-NMDA-receptor encephalitis: What we need to know as a NM physician”, Indian Journal of Nuclear Medicine, vol. 26, pp. 99-101, 2011.