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PET/CT in the evaluation of anti-NMDA-receptor encephalitis: What we need to know as a NM physician

Publication Type : Journal Article

Publisher : Indian Journal of Nuclear Medicine

Source : Indian Journal of Nuclear Medicine, Volume 26, Number 2, p.99-101 (2011)

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Keywords : adolescent, anti n methyl dextro aspartate receptor encephalitis, article, artificial ventilation, aspiration pneumonia, behavior change, blood pressure variability, bone marrow biopsy, bradycardia, brain metabolism, bruxism, case report, cerebrospinal fluid analysis, computer assisted emission tomography, facial expression, female, fluorodeoxyglucose f 18, haloperidol, human, hyperventilation, Intubation, leg movement, mastication, mental deterioration, oculogyric crisis, paraneoplastic neuropathy, promethazine, protein restriction, seizure, steroid, tachycardia, tic, whole body CT, whole body PET

Campus : Kochi

School : School of Medicine

Department : Department of Nuclear Medicine and Molecular Imaging

Year : 2011

Abstract : Anti N-methyl-d-aspartate receptor encephalitis (ANMDARE), also known as limbic encephalitis (LE), is a treatable rare disorder characterized by personality changes, irritability, depression, seizures, memory loss and sometimes dementia. It is classified under paraneoplastic syndrome (PNS) and produces antibodies against NR1 and NR2 subunits of glutamate aspartate receptor. It is thought to be closely related with malignancies like small cell lung cancer, ovarian teratoma and Hodgkins lymphoma, apart from testis, breast and rarely gastric malignancies. Non-paraneoplastic encephalitis cases are the ones with no detectable malignancy and may be triggered by severe infection. As nuclear medicine physicians, we must be aware of the diverse presentation of ANMDARE or LE and should include a whole body positron emission tomography / computed tomography (PET/CT) and not just brain PETCT during imaging. We describe the first case of PET/CT in an idiopathic ANMDARE Indian adolescent girl.

Cite this Research Publication : Sa Padma, Sundaram, P. Sa, and Marmattom, B. Vb, “PET/CT in the evaluation of anti-NMDA-receptor encephalitis: What we need to know as a NM physician”, Indian Journal of Nuclear Medicine, vol. 26, pp. 99-101, 2011.

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